Cushing's Syndrome
Cushing's syndrome results from prolonged exposure to excess cortisol, either from a tumour of the pituitary or adrenal gland producing excess hormone, or, most commonly, from long-term steroid medication use. It causes a wide range of physical and metabolic changes.
Common symptoms
- weight gain, particularly around the face, neck, and trunk;
- thin, fragile skin that bruises easily, with purple stretch marks;
- muscle weakness, high blood pressure, and high blood sugar.
What we offer
- the correct screening tests (late-night salivary cortisol, 24-hour urine cortisol, or dexamethasone suppression test);
- further testing to determine the underlying cause, including pituitary MRI or adrenal imaging;
- clear next steps depending on results, including surgical or medical treatment.
Confirming cortisol excess
Cushing's syndrome cannot be diagnosed from appearance or a single random cortisol result. Assessment uses validated screening tests selected for the clinical context, reviews steroid medicines in every form and confirms abnormal findings before investigating the source.
Treatment and monitoring
Treatment depends on the cause and may involve pituitary or adrenal surgery, medication to control cortisol, radiotherapy or oncology care. Follow-up monitors cortisol, blood pressure, diabetes, bone health, infection risk and pituitary or adrenal function. Steroid treatment must never be stopped abruptly without medical advice.
UK-wide video consultations
History and result review can usually take place securely by video. Timed samples, imaging and specialist procedures are arranged locally. Severe weakness, vomiting, collapse, confusion or inability to keep steroid medicine down requires urgent medical assessment.