Adrenal Conditions

Same hormone. Different clocks. How two modified-release hydrocortisone medicines try to return cortisol to the right hour—and why timing may matter as much as dose. Two medicines, one molecule—and two very different approaches to the 24-hour cortisol rhythm. THE SHORT ANSWER Both medicines contain hydrocortisone. Plenadren is taken on waking and recreates cortisol mainly during the day. Efmody is taken at bedtime and again in the morning, allowing cortisol to begin rising b

The body does not simply make cortisol; it keeps time with it. CORTISOL, CIRCADIAN RHYTHMS & CHRONOTHERAPY Why replacing cortisol is not only about giving the right hormone, but helping it arrive at the right moment. Most medicines are judged by a familiar question: how much should we give? Hormones make the question more interesting. With hormones, timing can matter almost as much as dose. Cortisol is not meant to sit at one steady level all day. It follows a carefully chore